Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers onto a target substrate. This electrostatic processing strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to 100 nm or less. In this study, we describe how electrospinning can be adapted to produce tissue-engineering scaffolds composed of collagen nanofibers. Optimizing conditions for calfskin type I collagen produced a matrix composed of 100 nm fibers that exhibited the 67 nm banding pattern that is characteristic of native collagen. The structural properties of electrospun collagen varied with the tissue of origin (type I from skin vs type I from placenta), the isotype (type I vs type III), and the concentration of the collagen solution used to spin the fibers. Electrospinning is a rapid and efficient process that can be used to selectively deposit polymers in a random fashion or along a predetermined and defined axis. Toward that end, our experiments demonstrate that it is possible to tailor subtle mechanical properties into a matrix by controlling fiber orientation. The inherent properties of the electrospinning process make it possible to fabricate complex, and seamless, three-dimensional shapes. Electrospun collagen promotes cell growth and the penetration of cells into the engineered matrix. The structural, material, and biological properties of electrospun collagen suggest that this material may represent a nearly ideal tissue engineering scaffold.The original research paper can be seen here.
Electrospinning of collagen nanofibers
sethfinley, , Electrospinning, Polymers, 0
The process of electrospinning produces polymeric fibers with diameters ranging from the micrometer to the nanometer scale. As the...
sethfinley, , Nanofibers, 0
The results of studies of patternedgrowth of vertically aligned carbon nanofibers (VACNFs) prepared by plasma-enhanced chemical vapor deposition are...
sethfinley, , Electrospinning, Nanofibers, 0
Nanofibers of polymers were electrospun by creating an electrically charged jet of polymer solution at a pendent droplet. After...
sethfinley, , Membranes, Nanofibers, 0
Electrospinning is a process by which high voltages are used to produce an interconnected membrane-like web of small fibers...
sethfinley, , Ceramics, Nanofibers, 0
Hollow nanofibers with walls made of inorganic/polymer composites or ceramics have been prepared by electrospinning two immiscible liquids through...
Functionalization of Electrospun TiO2 Nanofibers with Pt Nanoparticles and Nanowires for Catalytic Applicationssethfinley, , Catalysts, Electrospinning, Nanofibers, Platinum, 0
This paper reports a simple procedure for derivatizing the surface of anatase TiO2 nanofibers with Pt nanoparticles and then...
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